bacterial pathogens and resistance patterns in children with community-acquired urinary tract infection: a cross sectional study

background recent studies on bacterial pathogens causing urinary tract infection (uti) in children have shown high levels of antibiotic resistance in clinical settings. objectives we determined the common bacterial pathogens causing uti and their antimicrobial resistance patterns in iranian children. patients and methods the study subjects were 114 children (female subjects, 58.8%) with culture-proven uti categorized in the following 3 age groups: neonates (< 28 days,n = 45), infants (28 days to 2 years, n = 41), and children (> 2 years, n = 28). sensitivity testing was performed using the disc diffusion technique. results the most frequently cultured pathogens included escherichia coli (71.7%) and enterobacter (28.9%). uti caused by enterobacter was more commonly detected in neonates (60.6%) than in infants (21.2%) and children (18.2%). imipenem was the most activeagent against e. coli isolates (susceptibility, 97.3%), followed by ciprofloxacin (90.4%) and amikacin (82.9%). trimethoprim-sulfamethoxazole, cefalotine, and cephalexin were the least active agents, with 76.3%, 75.0%, and 73.7% of e. coli isolates exhibiting resistance,respectively. imipenem and ceftizoxime were the most effective antimicrobial agentsagainst enterobacter, with sensitivity rates of 85.2% and 71.4%, respectively. nitrofurantoin,ceftazidime, and cefalotine were the least active antimicrobial agents against enterobacter,with resistance rates of 92.3%, 66.7%, and 62.5%, respectively. conclusions the low susceptibility of common uti pathogens to cephalosporins may be because of their high rate of administration to children with uti in our population. a change in empiric therapy should be considered, especially in neonates.